The patron saint of Castiglione delle Stiviere is Saint Aloysius Gonzaga, born in the town: his feast is celebrated on 9 March, the day of his birth, in the Basilica Sanctuary of San Luigi Gonzaga; 21 June, instead, marks the anniversary of the saint's death.
The town also holds the Basilica di San Sebastiano, the church of Santa Maria della Rosa and the Castle of Castiglione delle Stiviere.