Lombardy

12 provinces · 1,506 towns · Population: 9,704,151

With ten million residents, Lombardy is Italy's most populous region — yet half an hour by train takes you from Milan's rush into landscapes writers have loved for two centuries: lakes Como, Garda and Maggiore, lined with villas and gardens dropping straight into the water. Milan itself runs on fashion, design and finance, but it also guards Leonardo's Last Supper, a UNESCO treasure since 1980, and a marble cathedral six centuries in the making.

Don't skip Bergamo's upper town, ringed by UNESCO-listed Venetian walls, or Mantua, the Gonzaga dynasty's dream in stone.