The patroness of Fraine is Saint Mary «Mater Domini» (Mother of the Lord), celebrated on 30 and 31 May and 1 June; the Santuario di Santa Maria Mater Domini is dedicated to her.
On 17 August the historical re-enactment «Fragine Medievale» is held and on 19 and 20 August the feast of Saint Vincent Ferrer and Saint Roch; the municipality also holds the Romitorio di San Domenico and the Chiesa di San Silvestro.