The patron of Lettopalena is Saint Vincent Ferrer, celebrated on 5 April; on the first Sunday of August the patronal feast is dedicated to Saint Vincent Ferrer and the Madonna Assunta.
In August the Festival dell'Aventino is also held, and among the sites of the municipality are the Chiesa di San Nicola di Bari, the Chiesa di Santa Maria Monteplanizio and the Pizzi di Palena.