The patron saint of Petilia Policastro is Saint Sebastian, the town's protector saint, celebrated on 20 January.
Every second Friday of March, in honour of the Spina, a pilgrimage to the sanctuary follows the Calvary procession, a costumed portrayal of the Way of the Cross. On Good Friday, instead, the Naca procession parades through the town's streets, with the Dead Christ and the Sorrowful Mother. The town also holds the Mother Church of Petilia Policastro and the Santissima Annunziata.