The patron saint of Calderara di Reno is Saint Vitalis, celebrated on 4 November.
The second weekend of September marks the anniversary of the Parish of Santa Maria di Calderara di Reno, during which the entire town takes part in a procession following the image of Santa Maria. The Settimana Calderarese offers, for a full week, various events such as film screenings on a giant screen and exhibitions. The town holds the Church of San Filippo Neri di Lippo and the Church of Sant'Elena, as well as the Church of San Michele Arcangelo.