The patrons of Medolla are Saints Senesius and Theopompus, celebrated on 21 May.
Its position on the border between the Duchy of Modena and Reggio, the Kingdom of Lombardy-Venetia and the Papal States, together with its proximity to Mirandola, capital of the feudal Pico della Mirandola family, favoured Medolla's development as a market town, remembered still in the historic Fiera di Bruino fair. The town also holds the Church of San Bartolomeo Apostolo.