The patrons of Sacrofano are Saints Blaise and Geminianus, celebrated on 3 February in the Church of San Biagio.
Traditionally on the second Sunday of September, the Palio della Stella is held, a historic event involving the town's districts with historical processions and competitions inspired by local tradition. In the locality of Borgo Pineto, Our Lady of the Assumption is also celebrated in September, while on 6 December, the feast of Saint Nicholas, the saint's ring-shaped pastries are traditionally prepared. The town also holds the Parco di Veio.