The patron saint of Monteprandone is Saint James of the Marches, celebrated on 28 November with religious and civic events spanning spirituality, food and wine, art and nature, over a week of celebrations.
In July, in the hamlet of Centobuchi, the feast of Saint Anne is held, marked by a renowned food fair. The town holds the Church of Sant'Anna and the Collegiate Church of San Nicolò di Bari, as well as the Library of San Giacomo della Marca.