The patron of Melpignano is Saint George, celebrated on 23 April.
Every year, in August, Melpignano hosts the final big concert of the Notte della Taranta, the largest music festival devoted to the revival and promotion of the Salento pizzica; the municipality of 2,209 inhabitants in the province of Lecce also holds the Convento degli Agostiniani, the Chiesa Annunziata and several menhirs, including the Calamauri, the Lama, the Minonna and the Scineo.