The patron of Orvinio is San Nicola di Bari, celebrated on the last Sunday of August.
The municipality also holds the Santuario di Vallebona, the Castello Malvezzi-Campeggi and the Chiesa di Santa Maria dei Raccomandati. In 1727 the Madonna di Vallebona was declared protectress of Orvinio; she is venerated and celebrated every year with great devotion.