The patron saints of Nepi are Saints Ptolemy and Romanus, celebrated on 24 and 25 August.
On Good Friday, the procession of the «Dead Christ» is held: the statues of Christ taken down from the cross and of the Sorrowful Mother are carried on the shoulders through the town's streets by the confraternities, in a silent funeral cortege. On Thursday, instead, the traditional visit to the Sepulchres takes place. The town also holds the Cathedral of Nepi and the Fortress of Nepi.