The patron saint of Appiano Gentile is Saint Stephen, celebrated on 26 December in the Church of Santo Stefano Protomartire.
Twice a year, on the first Tuesday of August and the first Tuesday of December, the traditional Fiera gròssa is held. In the first ten days of September, instead, the Sagra appianese takes place. The town also holds the Church of the Lazzaretto and the Villa Cagnola park.