The patron saint of Lizzanello is Saint Lawrence the Martyr, celebrated on 9 and 10 August in the Mother Church of San Lorenzo.
The town's calendar of feasts also includes the Feast and Fair of the Annunziata on 25 March, the Lizza Summer Festival on the first Saturday of July, and the Feast of Saint Aloysius Gonzaga on 20 and 21 June. The town holds the baronial palace of Lizzanello and the Church of Santa Maria delle Grazie.