The patron of San Donato di Lecce is Saint Donatus of Arezzo, celebrated on 6 and 7 August, with further celebrations on the 14th and 28th of the same month.
On the last week of May, in the hamlet of Cancellata, the Sagra te li cucummari is held, dedicated to cucumbers. The town also holds the Menhir delle Lete and the Menhir Curti Vecchi.