The patron of Mezzano is Saint George, celebrated on 23 April, to whom the Chiesa di San Giorgio is dedicated.
The town lies in the Primiero valley, between Imèr and Fiera di Primiero, and is a member of «I borghi più belli d'Italia» (Italy's most beautiful villages); the municipality also holds the Chiesa di San Giovanni and the church of Santa Fosca, while among the sites of its territory are the Paneveggio - Pale di San Martino nature park and the Cima Valsorda.