The patron of Tagliacozzo is Saint Anthony of Padua, celebrated on the last Sunday of August, as well as on 13 June.
In July and August, the international Midsummer Festival is held, hosting theatre and music performances also in the Palazzo Ducale, dating from the 14th century and commissioned by the Orsini family. The town also holds the Shrine of the Madonna dell'Oriente and the Oriental Museum of Tagliacozzo.