The patron saint of Manerbio is Saint Lawrence, celebrated on 10 August in the Church of San Lorenzo Martire.
For the Saint Faustinus fair, the town's gardens, particularly striking and rich in fine paintings and statues, are opened to the public every year. In May, the National Vespa Rally is held, organized by the Manerbio Vespa Club in Piazza Italia, while Grangibus is the children's literature festival with events, exhibitions, conferences and celebrations. The town also holds the Church of San Rocco and the Piccolo Teatro.