The patronal feast of Mesenzana is dedicated to the Purification of the Blessed Virgin Mary, Candlemas, on 2 February; the Chiesa della Purificazione di Maria Vergine is named after this title.
The municipality of 1,486 inhabitants in the province of Varese holds the Torre di Mesenzana, the Forte di Vallalta and the Osservatorio Buco di Diavolo.