The patron of Osimo has been, since 1967, Saint Joseph of Copertino, who died in the town's friary and rests in the basilica dedicated to him; before that year the patrons were Saint Victor and Saint Corona. The feast is celebrated on 18 September.
The treasury of the cathedral of San Leopardo also holds the reliquary of the Holy Cross attributed to Gian Lorenzo Bernini, which tradition holds contains a splinter of the Cross of Christ.