Among the patrons of Muro Leccese is the Holy Crucifix, celebrated from 2 to 4 May in the Chapel of the Crucifix.
The town's other patron, Saint Orontius, is instead celebrated on 26 August. Among the local traditions, the Thursday after Easter brings the feast of Santa Maria di Miggiano, and the second Sunday of July that of Saint Marina. The first Sunday of August sees the Stracittadina del Borgo, a 9-kilometre road race through the streets of the town.