The patron saint of San Casciano in Val di Pesa is Saint Cassian of Imola, celebrated on 13 August in the Collegiate Church of San Cassiano.
The municipal territory holds the Pieve di San Pancrazio and the Pieve di Santo Stefano a Campoli, as well as the Pieve di San Giovanni in Sugana. Among the town's places of interest are also Villa Poggio Torselli and the Niccolini Theatre.