The patron of Sant'Angelo a Cupolo is Saint Michael the Archangel, celebrated on 8 May in the Church of San Michele.
The town's hamlets have their own patrons: in Perrillo, Saint Donatus the Martyr is celebrated on 7 August, while in San Marco ai Monti the patronal feast falls on 5 August, the solemnity of Our Lady of the Snows, to whom the local church is dedicated. The town also holds the Convent of the Liguorini.