The co-patron of Clusone is Saint John the Baptist, celebrated on 24 June in the Basilica di Santa Maria Assunta e San Giovanni Battista; the patron, Our Lady of the Assumption, is instead celebrated on 15 August.
Between June and July the Clusone Jazz Festival is held, an event dedicated to jazz music that also involves other towns in the province of Bergamo. The town also holds the Chiesa dei Morti Nuovi and the Museo Arte Tempo.