The patron saint of Cascina is Saint Sebastian, celebrated on 20 January; Saints Innocent and Florentine are instead celebrated on the first Tuesday after the last Monday of May.
Having remained under Pisan rule throughout the 14th century, Cascina then passed under Florentine control: one of the main reasons for its development as a medieval town, together with the building of its walls, was precisely its position along the road linking the two cities, which repeatedly alternated in controlling the territory. The distinctive pentagonal-plan corner towers of the town walls still survive today, while a moat once ran alongside them, roughly corresponding today to the town's ring road. The municipal territory also preserves important medieval parish churches, such as that of Santa Maria and that of San Casciano, the latter part of the complex dedicated to Saints Hippolytus and Cassian.