The patron saint of San Nicola la Strada is Saint Nicholas of Bari, celebrated on the Tuesday after Easter.
The church dedicated to him stands set back from the Via Appia, separated from it by a large churchyard enclosed by a gate: the façade is tripartite and pedimented with pinnacles, foreshadowing the three-nave interior structure, where the high altar painting stands out among the other works. The town also holds the church of Santa Maria delle Grazie and that of Santa Maria della Pietà.