The patron of Acquapendente is Saint Hermes, celebrated on 28 August.
On the third Sunday of May, the Festa dei Pugnaloni is held, one of the oldest folk celebrations in Tuscia, originally also known as festa di Mezzomaggio: it is held to celebrate the feast of the Madonna del Fiore and brings together various events, including fairs and markets, with the pugnaloni, large floral panels, displayed in Piazza del Duomo. The town also holds the Co-Cathedral of the Holy Sepulchre and Torre Alfina.
