The patron of Castiglione in Teverina is the Holy Crucifix, venerated in the Church of Santi Filippo e Giacomo and celebrated from 30 April to 3 May. The town also celebrates a second patron, the Madonna della Neve, on 5 August.
On 13 June comes the feast of Saint Anthony of Padua. The town hosts the MUVIS Wine Museum, holds the Fontanile di Santa Lucia, and overlooks the Site of Community Importance of the Calanchi badlands of Civita di Bagnoregio.