The patron saint of Mariano Comense is Saint Stephen, celebrated on 3 August.
The town has five large districts, or rioni, that compete every year in the Palio delle contrade: Sant'Alessandro, Santo Stefano, San Rocco, San Maurizio and Sant'Ambrogio. The municipal territory also holds the Baptistery of San Giovanni Battista, the church of the Sacred Heart and that of Sant'Alessandro.