The patron of Lomello is the Holy Cross, celebrated on the second Sunday of May.
The third Sunday of June hosts a historical reenactment of the wedding of Theodelinda and Agilulf, a medieval feast with banquet and market. Between late August and early September, Gorgonzola, called «strachìn» in dialect, can be tasted at the Sagra dal Strachìn. The town holds the Basilica of Santa Maria Maggiore and the Castello Crivelli.