The patron of Cortandone is Saint Anthony the Abbot, celebrated on 17 January, to whom the Chiesa di Sant'Antonio Abate is dedicated.
In September the town celebrates the Festa delle Masche, the witches of Piedmontese lore, legendary figures of the Langa and Monferrato tradition; every weekend in November the local Pro Loco organises the Sagra della Bagna càuda.