The patrons of Serravalle Sesia are Saint Mary of the Assumption, Saint John the Baptist, Saint Nicholas, Saint James, Saint Eusebius and Saint Euseo, celebrated together on Pentecost Monday.
The municipal territory holds the Pieve di Santa Maria di Naula and the Sanctuary of Sant'Euseo, as well as the Church of San Giovanni Battista. The town also holds the Castello degli Avondo and the Oratory of San Bernardo.