The main patron of Lucera and of the diocese of Lucera-Troia is Santa Maria Patrona, venerated through a 14th-century icon donated by Charles II of Anjou: it is a wooden statue of the Brown Virgin, seated on a throne, cradling the Child with her left arm, counted among the Marian images the Holy See considers miraculous and for this reason crowned with a triple crown in 1806. Her feast is celebrated over the three days of 14, 15 and 16 August, known in Lucera dialect as «i fist d'agust» («the August feasts»), with a solemn procession on the 16th that returns the image to Piazza del Duomo.
The town's co-patrons are Saint Francis Anthony Fasani, Capitanata's first saint, and Saint Roch. Fasani, born in Lucera in 1681 and died in 1742, was a Franciscan friar beatified in 1951 by Pope Pius XII and canonised in 1986 by Pope John Paul II; venerated by the faithful as «the saint of rain», his remains rest in a crystal and bronze urn beneath the high altar of the basilica sanctuary named after him. The town's duomo, officially the cathedral basilica of Santa Maria Assunta, an example of Angevin-Gothic architecture built at the will of Charles II of Anjou and consecrated in 1302, is today a national monument and has been the diocesan sanctuary of Santa Maria Patrona since 1955.