The patron saint of Sant'Angelo Muxaro is Angelo of Jerusalem, also known as Angelo of Sicily, to whom the town's mother church is dedicated and from whom the first part of the place name derives: he is celebrated on 5 May. His image also appears on the municipal coat of arms, together with references to the Medici and Branciforte families, former feudal lords of the territory, an Arab's head recalling the historical tradition behind the origin of the name, two towers recalling ancient Camicus, and a heron, typical of the fauna of the Platani valley.
The town stands on a gypsum hill overlooking the middle Platani river valley and preserves one of the most important archaeological complexes of protohistoric Sicily, with rock-cut necropolises and monumental tombs attributed to the Sicani, a people active in the area between the 13th and 7th centuries BC. Nearby Monte Castello is identified by some historiography with ancient Camicus, the legendary capital of the Sicanian king Cocalus, remembered by classical sources as the place where Minos, who had come to Sicily in search of Daedalus, is said to have died: the episode also inspired a lost tragedy by Sophocles, the Καμίκιοι. The municipal territory also preserves the Grotta di Sant'Angelo Muxaro, recognised as a geosite of national interest.
