The patron of Gambatesa is Saint Bartholomew the Apostle, celebrated on 24 August in the parish church dedicated to him. The stone portal, topped by a triangular pediment, may date from the 16th century, as suggested by the 1523 baptismal font kept near the presbytery, decorated with the coats of arms of the town and the De Capua family. On the bell tower's façade stands a triptych with the Virgin at the centre and Saint Bartholomew the Apostle and the Cross-bearing Lamb at the sides; inside, the wooden choir is the work of local craftsmen.
The town also keeps the Castello di Capua, developed in Angevin times between the late 13th and 14th centuries on an earlier Lombard settlement, and passed in the 15th century to Andrea di Capua, from whom it takes its name. Inside it holds a cycle of frescoes painted in 1550 by Donato da Copertino, commissioned by Vincenzo I di Capua, duke of Termoli and count of Gambatesa: landscapes, grotesques, mythological and allegorical scenes, including figures of the cardinal virtues.
