The patron saint of Novi Ligure is Our Lady of the Snow, celebrated on 5 August.
Since 1607, the town has also celebrated the Feast of Saint Catherine, on 25 November, with a three-day fair through the town's central streets, offering the chance to buy local produce. Among the town's places of worship are the Collegiate church of Santa Maria Maggiore, the church of San Nicolò and the parish of San Pietro.