The patron saint of Città di Castello is Saint Florido, celebrated on 13 November: according to tradition, the town was destroyed in the 6th century by the Ostrogoth Totila and later rebuilt by Bishop Florido, later canonised and proclaimed the town's patron. The town's first documented bishop, when it was called Tifernum Tiberinum, was however Eubodius, attested in the year 465.
The cathedral of Saints Florido and Amanzio, the town's main religious building, is recognisable by its distinctive round bell tower of Ravenna origin; rich in works of art, it holds the patron saint's tomb in its crypt. The sanctuary of the Madonna delle Grazie, built in the 14th century as a Servite church, became a place of veneration for an image of the Madonna and Child made in 1456 by Giovanni da Piamonte, depicting the Virgin between Saints Florido and Philip Benizi. In Roman times, the town's most illustrious patron was Gaius Plinius Caecilius Secundus, known as Pliny the Younger, who according to one of his letters had a town temple built, completed in 103 or 104 AD, whose exact location is unknown today.
