The patron saint of Giugliano in Campania is Saint Julian of Sora, a martyr who devoted his life to the apostolate: having left Dalmatia at a young age to evangelise Campania, he was arrested by imperial soldiers in Anagni, flogged and taken to Sora. A delegation from Giugliano returning from his cult was welcomed with great rejoicing by the townspeople, who proclaimed him patron of the town; in 1631, in the church of Santa Sofia, the town's mother church which holds his relics, the artistic Treasury Chapel was built in his honour. The same church, designed in the 17th century by Domenico Fontana and completed by Domenico Antonio Vaccaro, has since 1632 held the tomb of the writer Giovan Battista Basile.
The town's co-patron is Our Lady of Peace, recognised as such by the Vatican in 1739, which ordered her feast to be held from the eve of Pentecost through the following Sunday. The municipal territory also includes the remains of ancient Liternum, a Roman colony founded in 194 BC near Lake Patria, where Publius Cornelius Scipio Africanus, victor over Hannibal at Zama, withdrew into voluntary exile and died in 183 BC: tradition still places his villa and tomb there today.