The patron saint of San Giuliano di Puglia, who also gives the town its name, is Julian of Sora, celebrated on 21 May, in the mother church dedicated to him: built in the 14th century, with a Latin-cross plan and three naves, it preserves the ancient facade with a trilobed Gothic portal, decorated with two carved lions and topped by three rose windows. The interior preserves medieval columns and 18th-century Baroque decorations. In 1490 the town was devastated by an earthquake that left only this church unscathed.
On 31 October 2002, a new, violent earthquake struck the centre of San Giuliano di Puglia, causing the collapse of the primary school and the deaths of twenty-seven children and a teacher: a tragedy the town still remembers today, including in the name of one of its fountains. In the locality of Piana Quadrata, during works for the temporary village built to house those left homeless after the quake, an archaeological site was discovered, investigated in 2004, which yielded the remains of a Roman villa and some late-antique burials.