The patron saint of Moliterno is Saint Dominic, celebrated on 4 August. According to tradition, the town was built after the destruction and invasion of Grumentum by the Saracens, which took place between 872 and 975: the resistance of the people of Grumentum who escaped the massacre gathered around a Lombard tower, giving rise to the new settlement.
The mother church of Santa Maria Assunta was built between the 12th and 13th centuries and over the centuries was the subject of various enlargements and reworkings: among the most interesting works held inside are a 16th-century panel depicting Saint Peter, by Simone da Firenze, and a distinctive 17th-century Last Supper by Giovan Francesco Ferro. The church of the Rosario, whose original structure dates from 1510, was enlarged in 1616 by the Dominicans, who gave it three naves with finely frescoed vaults and finely crafted wooden altars. In the church of Santa Croce is held the painting depicting the Deposition, a work attributed to the 17th-century painter known as Pietrafesa.
