The patron of Sestino is Saint Pancras, celebrated on 12 May, to whom the Pieve di San Pancrazio is dedicated.
On the last weekend of June the «Sagra della Bistecca Chianina» (Chianina Steak Festival) is held, with historical re-enactments in medieval dress, a palio between the districts of neighbouring towns, wine cellars, music and entertainment: the town centre turns into a large open-air banquet.