The patron saint of Nole is Saint Vincent the martyr, celebrated on 22 January. The parish church dedicated to him preserves, beneath the floor redone in 1984, the remains of a Romanesque church dating from 1100: the first written document mentioning it dates from 1312, when it was a provostry of the pieve of Liramo, a settlement now vanished between Ciriè and Nole. On 15 November 2006 the town's bell tower collapsed, badly damaging the parish church: after more than four years of restoration work, the church was solemnly reopened for worship precisely on 22 January 2011, while the new bell tower was inaugurated on 25 September 2021.
In 1336 Margaret of Savoy, regent of the castellany of Ciriè, allowed the inhabitants to build around the church a recetum, a fortified enclosure with walls, moats and drawbridges to defend people and goods: a stretch of the walls and the remains of the gate tower towards Villanova still survive today.
