The patron saint of Spello is Saint Felix of Massa Martana, celebrated on 18 May; one of the municipality's eight hamlets bears the name San Felice, a sign of the area's old devotion.
Declared «Colonia Giulia» by Caesar, whence the town's present nickname «Splendidissima Colonia Julia», and later «Colonia Julia Hispellium» by Augustus, who supported it in the war against Perugia and rewarded its loyalty by ceding it much of the territory taken from Perugia as far as the springs of the Clitunno, Spello today still preserves Porta Venere, from the Augustan era, with its two great Romanesque dodecagonal towers. Yet the town's most precious monument is the Collegiate Church of Santa Maria Maggiore, whose Baglioni chapel holds frescoes by Pinturicchio from 1500-1501 and a Deruta majolica floor from 1566, while nearby, in the church of Sant'Andrea, stands another work by the painter, the Madonna Enthroned with Saints, dated 1506-1508. Every year, coinciding with the feast of Corpus Domini, the town's streets are transformed for the famous Infiorate di Spello, carpets of flowers and petals forming elaborate figures along the route of the procession.
